Functional Genomics of DSB Repair Processes

There are a variety of DNA double strand break (DSB) sources. The DNA Damage Response is a reversible epigenetic process that synergizes repair efficiency by supporting engaged repair pathways. Importantly, emerging secondary repair pathways, fine mechanistic detail of primary repair, and the contexts to which they are all used remain to be fully elucidated. We seek to understand the genome-wide DSB repair fates and how they can be leveraged into effective therapies.

Our functional genomics projects cover many different fields: radiation and cancer biology, genome editing, immunology, and cell cycle phase-restricted DSB repair.