Frequent DNA:DNA contacts of DSB sites increase odds to translocate

Low-level and distributed genome-wide translocations to bait DSBs emphasize their relative DNA interaction frequencies. Specifically, they indicate a measurable level of genome instability and reveal aspects of genome organization hierarchy. This can be viewed by modulating the level of available DNA ends generated (i.e. ionizing radiation, oxidative free radicals, aberrant nuclease activity, topoisomerase adducts, replication fork stalling, etc.)