Publications

Preprint Server

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Publications

#29: Wang J, Sadeghi CA, Le LV, Le Bouteiller M, Frock RL. 2024 ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination. Science Advances July 31 PMCID: pending bioRxiv preprint: April 2024 - Press highlight

#28: Rangel V, Sterrenberg JN, Garawi A, Mezcord V, Folkerts ML, Caulderon SE, Garcia YE, Wang J, Soyfer EM, Eng OS, Valerin JB, Tanjasiri SP, Quintero-Rivera F, Masri S, Seldin MM, Frock RL, Fleischman AG, Pannunzio NR. 2024 Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities Nature Communications July 27 PMCID: PMC11283463 Research Square preprint: Sept. 2023

#27: Guan L, Viswanathan V, Jiang Y, Vijayakumar S, Cao H, Zhao J, Colburg DRC, Neuhofer P, Zhang Y, Wang J, Xu Y, Laseinde EE, Hildebrand R, Rahman M, Frock RL, Kong C, Beachy PA, Artandi S, Le QT. 2024 Tert-expressing cell contribute to salivary gland homeostasis and tissue regeneration after radiation therapy Genes and Development July 19 PMCID: pending

#25: Wang JL, Le Gall J, Frock RL, Strick TR. 2023. Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation. Nature Structural & Molecular Biology Oct 12 PMCID: PMC10643121 bioRxiv preprint: Nov. 2022

#26: Wang J, Sadeghi SA, Frock RL. 2024 DNA-PKcs Suppresses Illegitimate Chromosome Rearrangements Nucleic Acids Research May 22 PMCID: PMC11109964 bioRxiv preprint: Jan 2024

#24: Barghouth PB, Melemenidis S, Montay-Gruel P, Ollivier J, Viswanathan V, Jorge PG, Soto LA, Lau BC, Sadeghi C, Edlabadkar A, Zhang R, Ru N, Baulch JE, Manjappa R, Wang J, Le Bouteiller M, Surucu M, Yu A, Bush K, Skinner L, Maxim PG, Loo Jr BW, Limoli CL, Vozenin M-C, Frock RL. 2023. FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates. Radiotherapy and Oncology. Sep 9:188:109906. PMCID: PMC10591966 bioRxiv preprint: March 2023

Special Issue in 2022 FLASH Radiotherapy and Particle Therapy Conference (FRPT)

#23: Frock RL, Sadeghi C, Meng J, Wang JL. 2021. DNA end-joining: G0-ing to the core. Biomolecules. 11(10):1487. PMCID: PMC8533500

#22: Lattanzi A, Camarena J, Lahiri P, Segal H, Srifa W, Vakulskas CA, Frock RL, Kenrick J, Lee C, Talbott N, Skowronski J, Cromer MK, Charlesworth CT, Bak RO, Mantri S, Bao G, DiGiusto D, Tisdale J, Wright JF, Bhatia N, Roncarolo MG, Dever DP, Porteus MH. 2021. Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease. Science Translational Medicine. 13(598):eabf2444. PMCID: PMC8862191

#21: Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL. 2021. Ku70 suppresses alternative end-joining in G1-arrested progenitor B cells. Proc Natl Acad Sci U S A. 118(21):e2103630118. PMCID: PMC8166026 bioRxiv preprint: Feb 2021

“Abstract” Art

#20: Wang Q, Liu J, Janssen JM, Le Bouteiller M, Frock RL, Gonçalves MAFV. 2021. Precise and broad scope genome editing based on high-specificity Cas9 nickases. Nucleic Acids Research. 49(2):1173-1198. PMCID: PMC7826261

#19: Chen X, Tasca F, Wang Q, Liu J, Janssen, Brescia MD, Bellin M, Szuhai K, Kenrick J, Frock RL, Gonçalves MAFV. 2020. Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking. Nucleic Acids Research. 48(2):974-995. PMCID: PMC6954423

#18: Layer JV, Cleary J, Brown AJ, Stevenson KE, Morrow SN, Scoyk AV, Blasco RB, Karaca E, Meng F, Frock RL, Tivey T, Kim SS, Fuchs H, Chiarle R, Alt FW, Roberts SA, Weinstock DM, Day TA. 2018. Parp3 promotes long-range end-joining in murine cells. Proc Natl Acad Sci U S A. 115(40):10076- 10081. PMCID: PMC6176633 bioRxiv preprint: Feb 2018

Publications prior to 2018

#17: Willis NA, Frock RL, Menghi F, Duffey EE, Panday A, Camacho V, Hasty EP, Liu ET, Alt FW, Scully R. 2017. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature. 551(7682):590-595. PMCID: PMC5728692

#16: Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Gutierrez-Martinez P, Ebina W, Fasth A, Talkowski ME, Agarwal S, Alt FW, Rossi, DJ. 2017. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR/Cas9-mediated genome editing. Nature Biomedical Engineering. 1, 878-888. PMCID: PMC6918705

Featured in Nature Biomedical Engineering.

#15: Kumar V, Alt FW, Frock RL. 2016. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proc Natl Acad Sci U S A. 113(38):10619-24. PMCID: PMC5035843

Briefly highlighted in Cell Reports Facebook post 10/6/2016

#14: Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW. 2016. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. Journal of Experimental Medicine. 213(9):1921-1936. PMCID: PMC4995090

#13: Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. 2016. Detecting DNA double- stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nature Protocols. 11(5):853-71. PMCID: PMC4895203

#12: Frock RL, Hu J, Alt FW. 2015. Mechanisms of recurrent chromosomal translocations. In Janet Rowley, Terence Rabbitts, & Michelle LeBeau (Eds.) Chromosomal Translocations and Genome Rearrangements in Cancer. 27-51. DOI: 10.1007/978-3-319-19983-2

#11: Hu J, Zhang, Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW. 2015. Chromosomal loop domains direct the recombination of antigen receptor genes. Cell. 163(4):947-59. PMCID: PMC4660266

Featured in Trends in Molecular Medicine

#10: Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW. 2015. Genome-wide detection of DNA double- stranded breaks induced by engineered nucleases. Nature Biotechnology. 33(2):179-86. PMCID: PMC4320661

Featured in Nature Biotechnology and Molecular Cell

#9: Frock RL, Chen SC, Dai DF, Pak DN, Frett E, Lau C, Brown C, Wang Y, Rabinovitch PS, Santana LS, Ladiges WC, Worman HJ, Kennedy BK. 2012. Cardiomyocyte-specific expression of lamin A improves cardiac function in Lmna-/- mice. PLoS One. 7(8):e42918. PMCID: PMC3419749

#8: Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW. 2011. Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells. Cell. 147(1):107-19. PMCID: PMC3186939

Featured in Cell and Nature Reviews Genetics

#7: Hale JS, Frock RL, Mamman SA, Fink PJ, Kennedy BK. 2010. Cell-extrinsic defective lymphocyte development in Lmna-/- mice. PLoS One. 5(4):e10127. PMCID: PMC2853576

#6: Frock RL, Kudlow BA, Evans AM, Jameson SA, Hauschka SD, Kennedy BK. 2006. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev. 20(4): 486-500. PMCID: PMC1369050

#5: Smith ED, Kudlow BA, Frock RL, Kennedy BK. 2005. A-type nuclear lamins, progerias and other degenerative disorders. Mech Ageing Dev. 126(4): 447-460.

#4: Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK. 2004. A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A. 101(26): 9677-9682. PMCID: PMC470734

#3: Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK. 2004. Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol Cell Biol. 24(2): 595- 607. PMCID: PMC343811

#2: Deng WM, Schneider M, Frock R, Castillejo-Lopez C, Gaman EA, Baumgartner S, Ruohola-Baker H. 2003. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Development. 130(1): 173-184.

#1: Pfennig BW and Frock RL. 1999. The use of molecular modeling and VESPR theory in the undergraduate curriculum to predict the three-dimensional structure of molecules. J Chem Ed 7: 1018- 1022