Molecular and cellular consequences to impaired DSB repair deficiency

Cancer cells are incentivized to modulate their DNA repair activities in order to adapt and survive.  We are interested in unraveling these dependencies. Gif adapted from Ted-Ed

Cancer cells are incentivized to modulate their DNA repair activities in order to adapt and survive. We are interested in unraveling these dependencies. Gif adapted from Ted-Ed

Genetic impact to DSB repair: controlling the level of translocations.

Measuring the collateral damage of small molecule inhibitors of nuclear processes.

We will leverage the HTGTS platform to assess phenotypic responses of DSB repair genes to various “treatments”.

Stay Tuned! More to come in late 2024.

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Modulating DSB repair